Il Santuario sorge sul sacello eretto nel XVIII secolo sulla Porta S. Marco, uno degli ingressi della cinta muraria di Asti. Il Santuario nella forma attuale fu realizzato nel 1900 dal vescovo del tempo mons. Arcangelo Giacinti. La venerata immagine, raffigura la Vergine in trono con il Bambino risalente al XIV secolo.
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